منابع مشابه
GATA3 expression in gestational trophoblastic tissues and tumours.
AIMS GATA3 is a zinc-finger transcription factor that is important for trophoblast differentiation. GATA3 is sensitive for urothelial and breast carcinomas, but the specificity is low. The aim of this study was to investigate the expression of GATA3 in trophoblast-related tissues and neoplasia. METHODS AND RESULTS GATA3 immunohistochemistry was performed on 33 placentas, one atypical placenta...
متن کاملExpression of glypican 3 in placental site trophoblastic tumor
BACKGROUND Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that functions in embryonic cell growth and differentiation and is highly expressed in the placenta. GPC3 is mutated in Simpson-Golabi-Behmel syndrome, which is characterized by tissue overgrowth and an increased risk of embryonal malignancies. GPC3 has also been implicated in sporadic cancer, particularly hepatocellu...
متن کاملLmo2 and GATA-3 associated expression in intraembryonic hemogenic sites.
It is now widely accepted that hemopoietic cells born intraembryonically are the best candidates for the seeding of definitive hemopoietic organs. To further understand the mechanisms involved in the generation of definitive hemopoietic stem cells, we analysed the expression of the hemopoietic-related transcription factors Lmo2 and GATA-3 during the early steps of mouse development (7-12 dpc), ...
متن کاملFoxP3, GATA-3 and T-bet expression in elderly asthma.
BACKGROUND Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases....
متن کاملRegulation of GATA-3 expression during CD4 lineage differentiation.
GATA-3 is necessary for the development of MHC class II-restricted CD4 T cells, and its expression is increased during positive selection of these cells. TCR signals drive this upregulation, but the signaling pathways that control this process are not well understood. Using genetic and pharmacological approaches, we show that GATA-3 upregulation during thymocyte-positive selection is the result...
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ژورنال
عنوان ژورنال: American Journal of Surgical Pathology
سال: 2015
ISSN: 0147-5185
DOI: 10.1097/pas.0000000000000315